Do you feel stressed and/or occasionally anxious with matters related to your work or relationships? In this day and age, you’re not alone. National Institute of Mental Health statistics indicate that an estimated 19.1% of U.S. adults have anxiety disorder, and an estimated 31.1% of U.S. adults experience anxiety disorder at some time in their lives. Stress relief supplements, Stress and anxiety can lead to conditions such as depression, sleep disorders, heart disease, asthma, diabetes, obesity, gastrointestinal problems, Alzheimer’s disease, accelerated aging, erectile dysfunction, etc.*
StresNxiety is best natural stress relief supplements that has been formulated to nourish your brain in particular and the entire body in general to cope up with daily stressful situations in a healthy manner. Our criteria for the selection of ingredients to formulate this unique product are based on their derived properties that may address various disorders caused by stress and anxiety. StresNxiety ingredients are natural and have been evaluated for their benefits in clinical trials, making this product highly effective as natural stress and anxiety relief dietary supplement.*
- – Help reduce stress, anxiety, and irritability
- – Improve mood via increasing the levels of serotonin, dopamine, and norepinephrine
- – Improve symptoms of obsessive-compulsive disorder
- – Support fall asleep faster with quality sleep
- – May fight attention-deficit hyperactivity disorder (ADHD)
- – Powerful antioxidant properties
- – May boost brain functions
- – May help lower blood pressure
- – May improve circulation and heart health
- – Support a healthy central and peripheral nervous system
- – Promote healthy motor skills and coordination
- – Improve energy and endurance
- – Sedative and calming properties
- – May enhance cognition and memory performance
How To Use:
As a dietary supplement, take two capsules daily.
If you are pregnant or lactating, consult a health care professional before using this product.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Serving size: 2 capsules
No of servings per container: 30
|Ingredients||Common name||Part of the plant used||mg/ serving||% DV|
|Bacopa Monnieri ext||Brahmi||Whole plant||200||☨|
|Mucuna Pruriens ext||Kapikachhu||Root||175||☨|
|Nardostachys jatamansi ext||Jatamansi||Stem||175||☨|
|Hyperforatum pericum ext||St. John’s Wort||Aerial parts||150||☨|
|Valeriana jatamamsi Jones ext||Tagar||Root||150||☨|
|Gingko Biloba ext||Leaves||150||☨|
|Withania somnifera ext||Ashwagandha||Root||150||☨|
☨ Daily values not established
Below are some of the clinical trials conducted on StresNxiety ingredients.
St. John’s Wort (Hypericum perfporatum)
|Clinical use of Hypericum perforatum (St John’s wort) in depression: A meta-analysis.||Ng QX, Venkatanarayanan N, Ho CY. J Affect Disord. 2017 Mar 1;210:211-221.||https://www.ncbi.nlm.nih.gov/pubmed/28064110||St John’s wort is a popular herbal remedy recommended by Traditional Chinese Medicine (TCM) practitioners and licensed and widely prescribed for depression in many European countries. Selective serotonin reuptake inhibitor (SSRI) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.
In this study, a database of 5428 papers between 1-Jan-1960 and 1-May-2016 was reviewed. 27 clinical trials with a total of 3808 patients were reviewed, comparing the use of St John’s wort and SSRI.
Authors of this review study conclude that for patients with mild-to-moderate depression, St John’s wort has comparable efficacy and safety when compared to SSRIs. Follow-up studies carried out over a longer duration should be planned to ascertain its benefits.
|The acute effect of Hypericum perforatum on short-term memory in healthy adults.||Yechiam E, Ben-Eliezer D, Ashby NJS, Bar-Shaked M. Psychopharmacology (Berl). 2019 Feb;236(2):613-623.||https://www.ncbi.nlm.nih.gov/pubmed/30382352
|In this study, the authors reviewed in vitro, in vivo, and clinical evidence on the efficacy, safety, and mechanisms of action of St. John’s wort (Hypericum perforatum) and its active constituents in the treatment of psychiatric and neurodegenerative disorders. They noted that a number of antidepressant-controlled trials demonstrated that H. perforatum and its active ingredients, hypericin and hyperforin, possess antidepressant properties similar to those of tricyclic antidepressants and selective serotonin reuptake inhibitors but with fewer and milder side effects. The authors concluded that St. John’s wort may exert potent antidepressant effects and represents an efficacious and safe treatment. However, the current clinical evidence regarding the efficacy of H. perforatum in other psychiatric and neurodegenerative disorders is not sufficient to draw a robust conclusion.|
|Hypericum perforatum ( St. John’s Wort) in the treatment of psychiatric and neurodegenerative disorders: Current evidence and potential mechanisms of action.||Zirak N, Shafiee M, Soltani G, Mirzaei M, Sahebkar A. J Cell Physiol. 2019 Jun;234(6):8496-8508.||https://www.ncbi.nlm.nih.gov/pubmed/30461013||This study evaluated whether an acute treatment with Remotiv 500 and Remotiv 250 (500 or 250 mg of H. perforatum quantified to either 1 or 0.5 mg of hypericin) improved memory and sustained attention, as well as mood and state anxiety in healthy adults.
A single dosage, randomized, double-blind, placebo-controlled trial was conducted with 82 student participants (33 women). Each participant received placebo in one session and one of two dosages in the other session.
A significant positive effect of Remotiv 250 on digit span (mean Cohen’s d = 0.58; p = .01) was observed. By contrast, Remotiv 500 had a negative effect on digit span (mean d = - 0.48, p = 0.04). A similar effect emerged when factoring across tests of short-term memory. Both dosages improved mood (d = 0.60, p = .03).
The results indicate that acute treatment with small (250 mg) dosages of H. perforatum has a positive effect on the capacity of short-term verbal memory, and stress the importance of maintaining small dosages in nootropic applications.
Valerian Root Extract
|Valerian extract alters functional brain connectivity: A randomized double-blind placebo-controlled trial.||Roh D, Jung JH, Yoon KH, Lee CH, Kang LY, Lee SK, Shin K, Kim DH. Phytother Res. 2019 Apr;33(4):939-948.||https://www.ncbi.nlm.nih.gov/pubmed/30632220||Valerian root is the most commonly used herbal supplement for sedation and anxiolysis. The authors used electroencephalography (EEG) to investigate whether valerian root extract (VRE) affects resting-state connectivity changes and whether such changes are associated with clinical symptoms.
A 4-week, double-blinded, randomized, placebo-controlled clinical trial was conducted with 64 nonclinical volunteers suffering psychological stress where the participants received VRE (100 mg) or a placebo thrice daily. Compared with the placebo group, the VRE group exhibited significantly greater increases in frontal brain region alpha coherence across four electrode pairs, and these changes were significantly correlated with anxiolysis. The VRE group also exhibited significantly greater decreases in theta coherence across another four electrodes pairs.
The authors concluded that these findings indicate that VRE alters functional brain connectivity in relation to anxiety.
|The Ayurvedic plant Bacopa monnieri inhibits inflammatory pathways in the brain.||Michelle D.Nemetchek, Andrea A.Stierle, Donald B.Stierle, Diana I.Lurie. Journal of Ethnopharmacology Volume 197, 2 February 2017, Pages 92-100.||https://www.sciencedirect.com/science/article/pii/S0378874116304950||Bacopa monnieri (common name, bacopa) is a medicinal plant used in Ayurveda, the traditional system of medicine of India. It is considered to be a “medhya rasayana”, an herb that sharpens the mind and the intellect. Bacopa is an important ingredient in many Ayurvedic herbal formulations designed to treat conditions such as memory loss, anxiety, poor cognition and loss of concentration.
The aim of this study was to examine the ability of Bacopa to inhibit the release of pro-inflammatory cytokines from microglial cells, the immune cells of the brain that participate in inflammation in the CNS.
Various extracts of Bacopa were prepared and examined in the N9 microglial cell line in order to determine if they inhibited the release of the proinflammatory cytokines TNF-α and IL-6.
Bacopa inhibits the release of inflammatory cytokines from microglial cells and inhibits enzymes associated with inflammation in the brain. Thus, Bacopa can limit inflammation in the CNS, and offers a promising source of novel therapeutics for the treatment of many CNS disorders.
|Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.||Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. J Altern Complement Med. 2008 Jul;14(6):707-13.||https://www.ncbi.nlm.nih.gov/pubmed/18611150||This study aimed to evaluate effects of Bacopa monnieri whole plant standardized dry extract on cognitive function and affect and its safety and tolerability in healthy elderly study participants.
The study was a randomized, double-blind, placebo-controlled clinical trial with a placebo run-in of 6 weeks and a treatment period of 12 weeks. Fifty-four (54) participants, 65 or older (mean 73.5 years), without clinical signs of dementia, were recruited and randomized to Bacopa or placebo. Forty-eight (48) completed the study with 24 in each group.
Standardized B. monnieri extract 300 mg/day or a similar placebo tablet orally for 12 weeks.
Controlling for baseline cognitive deficit using the Blessed Orientation-Memory-Concentration test, Bacopa participants had enhanced AVLT delayed word recall memory scores relative to placebo. Stroop results were similarly significant, with the Bacopa group improving and the placebo group unchanged. CESD-10 depression scores, combined state plus trait anxiety scores, and heart rate decreased over time for the Bacopa group but increased for the placebo group.
B. monnieri has potential for safely enhancing cognitive performance in the aging.
Withania somnifera (Ashwagandha)
|An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study.||Lopresti AL, Smith SJ, Malvi H, Kodgule R. Medicine (Baltimore). 2019 Sep;98(37):e17186.||https://www.ncbi.nlm.nih.gov/pubmed/31517876||Ashwagandha (withania somnifera (l.) Dunal) is a herb traditionally used to reduce stress and enhance wellbeing. The aim of this study was to investigate its anxiolytic effects on adults with self-reported high stress and to examine potential mechanisms associated with its therapeutic effects.
In this 60-day, randomized, double-blind, placebo-controlled study the stress-relieving and pharmacological activity of an ashwagandha extract was investigated in stressed, healthy adults. Outcomes were measured using the hamilton anxiety rating scale (ham-a), depression, anxiety, and stress scale -21 (dass-21), and hormonal changes in cortisol, dehydroepiandrosterone-sulphate (dhea-s), and testosterone.
All participants completed the trial with no adverse events reported. In comparison with the placebo, ashwagandha supplementation was associated with a statistically significant reduction in the ham-a (p = .040) and a near-significant reduction in the dass-21 (p = .096).
These findings suggest that ashwagandha’s stress-relieving effects may occur via its moderating effect on the hypothalamus-pituitary-adrenal axis.
|A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.||Chandrasekhar K, Kapoor J, Anishetty S. Indian J Psychol Med. 2012 Jul;34(3):255-62.||https://www.ncbi.nlm.nih.gov/pubmed/23439798||Ashwagandha (withania somnifera (l.) Dunal) is a herb traditionally used to reduce stress and enhance wellbeing. The aim of this study was to investigate its anxiolytic effects on adults with self-reported high stress and to examine potential mechanisms associated with its therapeutic effects.
In this 60-day, randomized,Adaptogens are herbs that help in combating stress. Ayurvedic classical texts, animal studies and clinical studies describe ashwagandha as a safe and effective adaptogen.
The aim of the study was to evaluate the safety and efficacy of a high-concentration full-spectrum extract of ashwagandha roots in reducing stress and anxiety and in improving the general well-being of adults who were under stress.
A total of 64 subjects with a history of chronic stress were enrolled into the study in a single center, prospective, double-blind, randomized, placebo-controlled trial. They were randomized to either the placebo control group or the study drug treatment group, and were asked to take one capsule twice a day for a period of 60 days. In the study drug treatment group, each capsule contained 300 mg of high-concentration full-spectrum extract from the root of the ashwagandha plant.
The treatment group that was given the high-concentration full-spectrum ashwagandha root extract exhibited a significant reduction (p<0.0001) in scores on all the stress-assessment scales on day 60, relative to the placebo group. The serum cortisol levels were substantially reduced (p=0.0006) in the ashwagandha group, relative to the placebo group. The adverse effects were mild in nature and were comparable in both the groups. No serious adverse events were reported.
The findings of this study suggest that a high-concentration full-spectrum ashwagandha root extract safely and effectively improves an individual’s resistance towards stress and thereby improves self-assessed quality of life.
Nardostachys Jatamansi Exytact (NJE)
|Anxiolytic actions of Nardostachys jatamansi via GABA benzodiazepine channel complex mechanism and its biodistribution studies.||Razack S, Kandikattu HK, Venuprasad MP, Amruta N, Khanum F, Chuttani K, Mishra AK. Metab Brain Dis. 2018 Oct;33(5):1533-1549.||https://www.ncbi.nlm.nih.gov/pubmed/29934858||These results highlight biodistribution pattern of NJE, and also indicated that a 7-day treatment with NJE produced significant anxiolytic effects in mice and also a significant increase in brain monoamine and GABA neurotransmitter levels and suggests that anxiolytic effects of NJE are primarily and plausibly mediated by activating GABAergic receptor complex.|
|The role of antioxidant properties of Nardostachys jatamansi in alleviation of the symptoms of the chronic fatigue syndrome.||Lyle N, Gomes A, Sur T, Munshi S, Paul S, Chatterjee S, Bhattacharyya D. Behav Brain Res. 2009 Sep 14;202(2):285-90.||https://www.ncbi.nlm.nih.gov/pubmed/19375459||The results indicate that chronic fatigue syndrome (CFS) may lead to oxidative stress, which is mitigated by Nardostachys jatamansi extract (NJE) and so its antioxidant property may be responsible for anti-stress effect of NJE.|
|Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia.||Lopes Sakamoto F, Metzker Pereira Ribeiro R, Amador Bueno A, Oliveira Santos H. Pharmacol Res. 2019 Sep;147:104395.||https://www.ncbi.nlm.nih.gov/pubmed/31412272||L-theanine is an amino acid naturally found in green tea (camellia sinensis) and some other plant extracts. Recent clinical studies have proposed promising adjuvant effects of L-theanine for the negative impact of anxiety and psychological stress on health. Published data suggests that L-theanine administered at daily doses ranging from 200 to 400 mg for up to 8 weeks are safe and induce anxiolytic and anti-stress effects in acute and chronic conditions. L-theanine at doses lower and higher than these may also show promising therapeutic potential..|
|Clinical study on compound prescription with Valeriana Jatamansi Rhizoma et Radix in treatment of generalized anxiety disorder.||Bai JS, Zhang QC, Guo DD, Zheng HZ, Shi JL, Guo JY. Zhongguo Zhong Yao Za Zhi. 2017 Dec;42(24):4888-4892.||https://www.ncbi.nlm.nih.gov/pubmed/29493163||This study was aimed to observe the clinical efficacy of anxiolytic compound prescription with Valerianae Jatamansi Rhizoma et Radix (ACPV) in treating liver Qi stagnation and feel ill at ease type generalized anxiety disorder (GAD). Sixty patients were enrolled in the study finally (30 cases in each group). Patients in treatment group (n=34) was treated with ACPV (Valerianae Jatamansi Rhizoma et Radix). Patients in control group (n=33) were treated with Deanxit. [a drug (Flupentixol +Melitracen) for treating depression]. As compared with baseline, HAMA scores in both groups were significantly decreased at 2 weeks and 4 weeks (P<0.05, P<0.01). After 2 weeks and 4 weeks treatment, the TCM syndrome score in both group was also significantly improved (P<0.01). Moreover, the salivary cortisol levels in both groups were also decreased at 2 weeks and 4 weeks (P<0.05, P<0.01). The total efficiency between two groups had no statistically significant difference after 2 weeks treatment and 4 weeks treatment.|
Celastrus paniculatus (Jyothishmathi)
|Neuroprotective effect of Celastrus paniculatus on chronic stress-induced cognitive impairment.||Bhagya V, Christofer T, Shankaranarayana Rao BS. Indian J Pharmacol. 2016 Nov-Dec;48(6):687-693.||https://www.ncbi.nlm.nih.gov/pubmed/28066108||Several studies report that chronic stress results in impaired spatial learning and working memory and enhanced anxiety-like behavior. Celastrus paniculatus (CP), a traditional ayurvedic herbal medicine, was used to treat cognitive deficits in mentally retarded children. CP oil has been reported to have neuroprotective and antioxidant activities.
In this study, chronic stress was induced by subjecting rats to restrainers for 6 h a day for 21 days. CP oil (400, 600 mg/kg) or vehicle was administered intraperitoneally (i.p.) after stress protocol once a day over the next 14 days. Stressed rats showed enhanced anxiety-like behavior in EPM (P < 0.001) and impaired performance in RAM (P < 0.001) and T-maze tasks (P < 0.001) compared to normal animals. In contrast, CP oil treatment to these rats improved their performance in both RAM (P < 0.001) and T-maze (P < 0.001). In addition, CP oil significantly reduced stress-induced anxiety behavior (P < 0.001).
Chronic treatment with CP oil is to improve cognitive abilities in chronically stressed rats. This study provides a novel perspective on beneficial effect of herbal therapy on stress-induced cognitive dysfunctions.